منابع مشابه
Genetic Analysis of Complex Diseases
Neil Risch, in a series of seminal papers in 1990 (1, 2), demonstrated the utility of sibpair linkage analysis in identifying genes for complex genetic traits. In doing so, he defined what is the current paradigm for the genetic dissection of common complex genetic diseases. The recent Perspective by Risch and Kathleen Merikangas (3) again shapes the future of human disease gene mapping by defi...
متن کاملGenetic analysis of complex diseases.
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متن کاملthe recurrence risk of genetic complex diseases
complex inherited diseases affected by an interaction between collective effects of the genotype at one or multiple loci either to increase or to lower susceptibility to disease, combined with a variety of environmental exposures that may trigger, accelerate, exacerbate, or protect against the disease process. the new aspects of genetic techniques have been opened for diagnosis and analysis of ...
متن کاملComplex Genetic Diseases
*Please consult the online schedule for this course for the definitive date and time for this lecture. Key Concepts vs Supplementary Information: The syllabus is meant to accompany the lectures and the material covered (other) than that in italics) is considered important to your understanding of the subject. Key items are marked in bold. Supplemental information is marked in italics. Lecture O...
متن کاملComplex Multifactorial Genetic Diseases
A trait is often of interest by virtue of being either highly desirable, for example intelligence, or highly undesirable, for example cancer. Genetic influence over the trait can be established inmanyways including twin studies, clustering statistics and statistical modelling. Once the existence of a genetic component has been established, the next step is to locate the genes involved. The ease...
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ژورنال
عنوان ژورنال: Science
سال: 1997
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.275.5304.1327